	   SnapGene      FcggtgcgggcctcttcgctattacgccagatccttttgttgtttccgggtgtacaatatggacttcctcttttctggcaaccaaacccatacatcgggattcctataataccttcgttggtctccctaacatgtaggtggcggaggggagatatacaatagaacagataccagacaagacataatgggctaaacaagactacaccaattacactgcctcattgatggtggtacataacgaactaatactgtagccctagacttgatagccatcatcatatcgaagtttcactaccctttttccatttgccatctattgaagtaataataggcgcatgcaacttcttttctttttttttcttttctctctcccccgttgttgtctcaccatatccgcaatgacaaaaaaatgatggaagacactaaaggaaaaaattaacgacaaagacagcaccaacagatgtcgttgttccagagctgatgaggggtatctcgaagcacacgaaactttttccttccttcattcacgcacactactctctaatgagcaacggtatacggccttccttccagttacttgaatttgaaataaaaaaaagtttgctgtcttgctatcaagtataaatagacctgcaattattaatcttttgtttcctcgtcattgttctcgttccctttcttccttgtttctttttctgcacaatatttcaagctataccaagcatacaatcaactccaagcttgaagcaagcctcctgaaagatgaagctactgtcttctatcgaacaagcatgcgatatttgccgacttaaaaagctcaagtgctccaaagaaaaaccgaagtgcgccaagtgtctgaagaacaactgggagtgtcgctactctcccaaaaccaaaaggtctccgctgactagggcacatctgacagaagtggaatcaaggctagaaagactggaacagctatttctactgatttttcctcgagaagaccttgacatgattttgaaaatggattctttacaggatataaaagcattgttaacaggattatttgtacaagataatgtgaataaagatgccgtcacagatagattggcttcagtggagactgatatgcctctaacattgagacagcatagaataagtgcgacatcatcatcggaagagagtagtaacaaaggtcaaagacagttgactgtatcgccggaatttgtaatacgactcactatagggcgagccgccatcatggaggagcagaagctgatctcagaggaggacctgcatatgATGGCTTTCAAGGAAATCGCAATGTTTTCCAGTTTAGTGGTGGTCATCATAAGCTACAATGTACTAGAAAGCAATGCATTAATGATGCAACCATTAATAGACCAAGATTTCTGTGCAGTAAAAGCTAGTTTGTACGAATTGGGAGAGGCTGAGATGAACTTGATGGACGATTCGCAGACATTAAACGACATGCAAAGAGAATATTTTGCTGGAAAAGTTGACTATTCTGCTGTGGAAAGAGCAAGGAATGAACTTAATAAGTCCAAAAACAAGTGGTTCCAAAAAGTTATACAATATCTCAAGGCAACAAATGAATTTGAGCCCACAATCAACTATCAAACCTCAGATCCACAAAAAGTTTACCATCAAATGGATGACTTGGACAATTATAAAGATGCTCTAGATGATATGCATGAAAATATCCTTAAATCAATGTCCCCTACCGTAGCCCAACCTGTTGTAGCATAAggatccgtcgacctgcagcggccgcataactagcataaccccttggggcctctaaacgggtcttgaggggttttttgcgcgcttgcagccaagctaattccgggcgaatttcttatgatttatgatttttattattaaataagttataaaaaaaataagtgtatacaaattttaaagtgactcttaggttttaaaacgaaaattcttattcttgagtaactctttcctgtaggtcaggttgctttctcaggtatagcatgaggtcgctcttattgaccacacctctaccggcatgcaagcttggcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaagaacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaacctgaggctatggcagggcctgccgccccgacgttggctgcgagccctgggccttcacccgaacttggggggtggggtggggaaaaggaagaaacgcgggcgtattggccccaatggggtctcggtggggtatcgacagagtgccagccctgggaccgaaccccgcgtttatgaacaaacgacccaacaccgtgcgttttattctgtctttttattgccgtcatagcgcgggttccttccggtattgtctccttccgtgtttcagttagcctccccctagggtgggcgaagaactccagcatgagatccccgcgctggaggatcatccagccggcgtcccggaaaacgattccgaagcccaacctttcatagaaggcggcggtggaatcgaaatctcgtgatggcaggttgggcgtcgcttggtcggtcatttcgaaccccagagtcccgctcagaagaactcgtcaagaaggcgatagaaggcgatgcgctgcgaatcgggagcggcgataccgtaaagcacgaggaagcggtcagcccattcgccgccaagctcttcagcaatatcacgggtagccaacgctatgtcctgatagcggtccgccacacccagccggccacagtcgatgaatccagaaaagcggccattttccaccatgatattcggcaagcaggcatcgccatgagtcacgacgagatcctcgccgtcgggcatgctcgccttgagcctggcgaacagttcggctggcgcgagcccctgatgctcttcgtccagatcatcctgatcgacaagaccggcttccatccgagtacgtgctcgctcgatgcgatgtttcgcttggtggtcgaatgggcaggtagccggatcaagcgtatgcagccgccgcattgcatcagccatgatggatactttctcggcaggagcaaggtgagatgacaggagatcctgccccggcacttcgcccaatagcagccagtcccttcccgcttcagtgacaacgtcgagcacagctgcgcaaggaacgcccgtcgtggccagccacgatagccgcgctgcctcgtcttgcagttcattcagggcaccggacaggtcggtcttgacaaaaagaaccgggcgcccctgcgctgacagccggaacacggcggcatcagagcagccgattgtctgttgtgcccagtcatagccgaatagcctctccacccaagcggccggagaacctgcgtgcaatccatcttgttcaatcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgaacgaagcatctgtgcttcattttgtagaacaaaaatgcaacgcgagagcgctaatttttcaaacaaagaatctgagctgcatttttacagaacagaaatgcaacgcgaaagcgctattttaccaacgaagaatctgtgcttcatttttgtaaaacaaaaatgcaacgcgagagcgctaatttttcaaacaaagaatctgagctgcatttttacagaacagaaatgcaacgcgagagcgctattttaccaacaaagaatctatacttcttttttgttctacaaaaatgcatcccgagagcgctatttttctaacaaagcatcttagattactttttttctcctttgtgcgctctataatgcagtctcttgataactttttgcactgtaggtccgttaaggttagaagaaggctactttggtgtctattttctcttccataaaaaaagcctgactccacttcccgcgtttactgattactagcgaagctgcgggtgcattttttcaagataaaggcatccccgattatattctataccgatgtggattgcgcatactttgtgaacagaaagtgatagcgttgatgattcttcattggtcagaaaattatgaacggtttcttctattttgtctctatatactacgtataggaaatgtttacattttcgtattgttttcgattcactctatgaatagttcttactacaatttttttgtctaaagagtaatactagagataaacataaaaaatgtagaggtcgagtttagatgcaagttcaaggagcgaaaggtggatgggtaggttatatagggatatagcacagagatatatagcaaagagatacttttgagcaatgtttgtggaagcggtattcgcaatattttagtagctcgttacagtccggtgcgtttttggttttttgaaagtgcgtcttcagagcgcttttggttttcaaaagcgctctgaagttcctatactttctagagaataggaacttcggaataggaacttcaaagcgtttccgaaaacgagcgcttccgaaaatgcaacgcgagctgcgcacatacagctcactgttcacgtcgcacctatatctgcgtgttgcctgtatatatatatacatgagaagaacggcatagtgcgtgtttatgcttaaatgcgtacttatatgcgtctatttatgtaggatgaaaggtagtctagtacctcctgtgatattatcccattccatgcggggtatcgtatgcttccttcagcactaccctttagctgttctatatgctgccactcctcaattggattagtctcatccttcaatgctatcatttcctttgatattggatcatactaagaaaccattattatcatgacattaacctataaaaataggcgtatcacgaggccctttcgtctcgcgcgtttcggtgatgacggtgaaaacctctgacacatgcagctcccggagacggtcacagcttgtctgtaagcggatgccgggagcagacaagcccgtcagggcgcgtcagcgggtgttggcgggtgtcggggctggcttaactatgcggcatcagagcagattgtactgagagtgcaccatagatcaacgacattactatatatataatataggaagcatttaatagaacagcatcgtaatatatgtgtactttgcagttatgacgccagatggcagtagtggaagatattctttattgaaaaatagcttgtcaccttacgtacaatcttgatccggagcttttctttttttgccgattaagaattaattcggtcgaaaaaagaaaaggagagggccaagagggagggcattggtgactattgagcacgtgagtatacgtgattaagcacacaaaggcagcttggagtatgtctgttattaatttcacaggtagttctggtccattggtgaaagtttgcggcttgcagagcacagaggccgcagaatgtgctctagattccgatgctgacttgctgggtattatatgtgtgcccaatagaaagagaacaattgacccggttattgcaaggaaaatttcaagtcttgtaaaagcatataaaaatagttcaggcactccgaaatacttggttggcgtgtttcgtaatcaacctaaggaggatgttttggctctggtcaatgattacggcattgatatcgtccaactgcatggagatgagtcgtggcaagaataccaagagttcctcggtttgccagttattaaaagactcgtatttccaaaagactgcaacatactactcagtgcagcttcacagaaacctcattcgtttattcccttgtttgattcagaagcaggtgggacaggtgaacttttggattggaactcgatttctgactgggttggaaggcaagagagccccgaaagcttacattttatgttagctggtggactgacgccagaaaatgttggtgatgcgcttagattaaatggcgttattggtgttgatgtaagcggaggtgtggagacaaatggtgtaaaagactctaacaaaatagcaaatttcgtcaaaaatgctaagaaataggttattactgagtagtatttatttaagtattgtttgtgcacttgccgatctatgcggtgtgaaataccgcacagatgcgtaaggagaaaataccgcatcaggaaattgtaagcgttaatattttgttaaaattcgcgttaaatttttgttaaatcagctcattttttaaccaataggccgaaatcggcaaaatcccttataaatcaaaagaatagaccgagatagggttgagtgttgttccagtttggaacaagagtccactattaaagaacgtggactccaacgtcaaagggcgaaaaaccgtctatcagggcgatggcccactacgtgaaccatcaccctaatcaagttttttggggtcgaggtgccgtaaagcactaaatcggaaccctaaagggagcccccgatttagagcttgacggggaaagccggcgaacgtggcgagaaaggaagggaagaaagcgaaaggagcgggcgctagggcgctggcaagtgtagcggtcacgctgcgcgtaaccaccacacccgccgcgcttaatgcgccgctacagggcgcgtccattcgccattcaggctgcgcaactgttgggaagggcgat  B�                  *      
   %            (               "      (   ,   <      )   $      !                                                +                  !      !   +       '   (      &         !                  #         &   <   '                  !   0   &   %   '   8       4   H   i   6      '   /            %            (      '   *   !   .   #   #   '   6         (                     &   ,                                                 #   %            (      (   (                        /            /   6                  %   &   (         %   +      /   !   j   :      %   (   0               !   %                +         !                         %                           0         *      "   ,   /                '                                     $      #      )   )                               !               "                        � ãgÔV	
ÑÒÓØÝËÀ÷Q’ _ ‘ c’§ÕW	T
/Þ&‚Æ
y“²9 . ähÔÙt¦É‘ÌÚ
Áæð¶2ÎR  ¹ �Í?êœ
ž¿ðª)TâÄçÚøÿ$ÆÎ> � ’ dNÞáö“ÖËƒ':Jú¤ÇÆú	F@w¦®@zÁ* �ª£¸‡´ØïúQ¨b	‡	
U
ŠßåãœŠýwLÍÕÛK�ë 7Rän”®³: ` ñýyÚX	:
ê0KÎî¤� *¿C
 ; ùª‚ï	'Ëd %  / ‡ á ,iÞ	„
-C½ÕÚ
§×.’Ûu~‡çñqay—©¸%Y ä å'Ó(	=	w
Í
ç
"i–·ÊçR˜Â`· ”ÆÞE	Àu%’Í~T€¡à%›3íÏ v �š/Áß	Š
748¢äÚÐÔtBâªêiRSá( Š IÎ@Ûë!	:	 	á	 
]
*ñ«Û*fpˆiyè[Ûí)Ž%œ¥ÇÏ? K ‘4ûÿ
¥š!(0Uã#HÅð[
‡>_„;§Õ º «E˜	®	�
Q”²u«‰ùý~L*  .íÉw	‚	”	FŸÀùö˜Fg ��+ Ž áßô÷–ÝÙÜ	 ’Ìšàeý
�A§W" “ ÕOf‹”œÊ×=½E1;K™ØË%4ÆR¥ûÑx@¯AÈ¨ e�¯sÜ
6‘‰I;¶Àæ!%G}’÷Óë( Ù ÑâôDLw$	o	¿	¸„c~(z :›·Úû?—ôÈÇ†B{‰Â, =žíæûFXž×ˆçR
V
>[zólæ®ðUcm�„óoƒ†ÒM³TL‘8¯´;< «öHô>°ëHÙð¤Ÿ(©c	ä	‹â àéä
»áO[Ì%Gxÿˆîþ”6Š¡îõtÍìßIpç*CS¡•ª·½ B¤*qµ�Ìû>CÄP	}Þ1°4r±ï ÈÖà–‰¿)   î [¹¡ÿg	ˆ	©
^Ë,;±AXl‹âþMïJÇ PÎÜWYÓ!åú7oŸ$ Þ šÊÞø1Yž§z�˜s †ÆË3	4í‘�À„¨Dz|�7( • ¥ þ"=U›Y	ù	;
i‹Þ!¢¥aê+Í'6¬$”eÊ! a ÊåòAo®NU×1?ê5Èù7”Ú/¢Yû'†ƒ  í_Û ëöþLX¿ÏG•žï=+-Á «¼	Ï	¬B„§}i� ¬ ± �¡·½šàh{¡¶Àƒë	ì
¢6qÌÚöG”Í4± < Ä $‹´Q¨Âá}Œ	ð	ñ
²®®¿.eÁ rÚúiãì*
»
(C§ÛÄ ˆ â ¡L*-íß	[
AD¾ÖÛ¨Ø–JŽ‚b¬þ£ (Š&um	/o)ªˆ#-rz(5 0 Rgx$\…
¡
�“9eèòlÁ,˜ª¹&ÕÚ  4Iwvj³
£
.N¼!UæüxIÜvŒa#šÃÒZ „ ù �ÂÑ¾t
‡
'—¸ËèqÝd�™‹aùÜ @’»{±^>	�	Î
è
‹‘…Â¹cü3 »<Y_î æ(i¬zÔå)	x
#cj�ô€÷´r‰SBÃÈ^'I¸³ü 2 å B‰¸w¡n· % s vyÐ¥ÞÎÇŒš	“¯&1;ê&4všÐ×6 ;#h.F	�*—“ykxQá¤Z‘î_jv�+ ( Uˆ¬%…k•ß£	
ÁÉo5R‘ÎÁU}ŽèFz�¢ègyx.Gœë÷àJ Ó–œ	%
€
Ž
²
8vq»cÎ¥ô¶"æd”Ú Íiàà¤°	‹
-5ýQÛw“Ñã(ôëT �7›0ÂØ	8j9^£=(C«Öà­SÙ
â w |\T‚×
\…³Õ™Z•c¹�ƒœpµM÷ 
¸B
Þ
ÞKÙå�_uqjkí!  ‹ ëÒÜ	&	;	+»îr	† âD¢ØP¾½äî|¤#Äß yÏA"	â	¶¬gq{‰j|ÉY—ÖÐý	&�¦»@! 	Šã˜	¡	
Y
ò3PÜ+õS¿/xŽæ7cu�\wÞ*�:]tì+ JK&(�Ðì	
^
Â
pÝpÆvz„©éñÓ _�ÜK™¬öuÜÈÐê 	.  äx³è._	 ÑÔß›"-äû$X¸W›Êuˆ?ƒ“Ô' L PŠ"wéL\Åö5 q	|	¦Í¿)*†WT’Ñð/AYç…Ã<Ð¨Ö0( LÐlÿQ ÔñúÙüU¼Á	¹1V	‡ö?¼-Þñ\O^`sL Áð¸’¥
–I|ÆÕl +Ö%5ˆ2d& ÛYˆê™Õê¹
		�	q
™
ž
¿
w´³Èxv�«ó<¹Õãïú«³^Òç+  » aÆþl¬¾:�6y0R•Ô"aŸÞŠâÊ âF	*Êœö3
`
0¬Óiþz›ømÌ±þ©ÉB×M�‹! .6’ã5‘îþ	/	¯	Ò	

k
’
ršP·Z‰¾ÂMg®žœMŠ !4±ÓîN•	0
¤gØ¯óNëþ¦ú.GÃ×�ž\™ý  3MÖ1µÊx	ƒ	ù
}²Îé÷6[™�èò€ l"  Ö /íZ	clF
Ä
G Á›^e®6®> ü FÅ˜´	·
§ºú!ó§€CP�ë#hÒÅD,} � â�ÌU	.�¥Ã�ÊÙþÍ#x±Í=# ©üàõøùÙa	†	î	éJäÍ›&9‰vùÌÚ�Jùê?B?Q­À † €™“ÀÅÒÞÝ	v
‰
!$æ-Ïs}á—_¨ìX Hª—3Ú9	v	�	“	­	ÿ	)“eo/ˆïZf=Ž:œ)& ØŠŒó•ÉóØÛ	5�HšÙ¿Êß$3–Å ü…ŒÐ‘?Aêˆ< Ÿ =Z�¯ÖpæGËO	f	Z]áòè°TWbl	áLº
3INq°ÆËî‚…$FÇSV5Xßô•ÌÒˆÞ oæB¾ù©¶'  ” ¤ É÷!0<@n�^Ž—ø	Öõ>W¾F”2<4éÌì&5,ƒ“¡y…6É « ° Ã  ¼q³ÙPg hµë
¦¦Ì­¾°ÀÃ 3HQf Kv)w‰[t@nå(‹`"�ÑÔÙ ?hŽ‘z°b€Š·Ác Š&Høû :T¤$„Ý"jg
7€’n–pº¤çóµwcw“£ßI 	£×	Ý
Jü<^'Yp›ö~ì! ê%	X
ºo…ŸáôC¡^œÛÏ.üO˜«åõ¼ã£\ºÃÞ0 Àï!ÏèkãKõÓùØTp	{	À	ÐÓ¸•¾,)W{†õ,.@ÕÉN]4‡Ïc& ÚÅáý-½é9€5x¸.	
j
˜
™¶€;¸Ôfâ�°¨ÈAÖL]‰Š% û 
ìÒEÄ0Mb¶
|¹ š×ò¦ÍòdêýZœ¥ù-5­ÑC|˜' ¨©˜ø2Ø8	u	€	’	è-Iãdn,ˆ|‡îø–ø<é>9>w¬°¿<8 ¯ Â Ÿ»ö<Y²Ø /‰ŸmÈò�e	÷	ê
\�ñôç¯Va¥à2p¯í„è¾2U4’ÞóÏ‡�¬½>¿å½éøµ  >Sg2GPŸuÜ!ifvˆZÖ	?mä'òŠ´võHØ4 îÄÎàçëü,è8J4Sa
W
—
{Ïñ”žµ+óB…ô]+¬ÓNªä»ÐM3 K¢[b—¹H §ºRõ+;~±.—žI~ÇÛñ hŒ‡Y`7	d	t		‘	ö	ŽçH~â“ßã1\®ì*«í&½ 1‰©ã•ò÷;uÎÿ«¼J¾¼÷av–«¸¾i ’“”•¬­®MNOPQ)*?@w}ì}Úfg¥mnopqš s	~	�	�	È	É	Œ�ãäåæ!FGfgáåÝÞ¼½â‡Œ�	
§¨©ªHÖ×Ø¨ïÿTU‹¢£ïðñöíþ	ª»q½ÊÜÝDmª»6 –¯Imí:u¦°br€¡)Ê	aht¾ÆPŽÍIyÙ qV¤î
rŠ´ËÒÞè+ETny„¢«¶i R ¾ ÷Ax¼W›ªå	¨¬"ê?æÂ-ˆªÐð7Œà' ¶ Œ—î%?NVü;vµpÁiÿß±Q�ÎTzÚCr—Vs‹µß/ 6 j œ ó BEJn¼+r½eÍ*§cs@	ÁT2{¿Ç¡Ä[É×WEUe¥ÉŠÌé,Fb™À Í °Cy¶Ž?†9D�¢*;†b%¢J°üáåW×ïÓUoz €Ö¥L±ÅQ	Ë	uy~Yg5s²ð»5…£¬·Dj ë ´$½œÍ\	ë@çÑtŒðVl”ÓQñX1û %  ¡ ¿ Æ\º`”7Eh	_©<HmÿÃ.K‰«Èé'!ÑZÔÅÇæ ï RøÚ_¢ Põ³|Ð
K#Ì²YdÏÝo"2 N S By^XÉþ«‰	æ	ª
â
­�-÷BãN8M�9á•8pð 9 · ß ›ïÜ¨w˜ à…uŒ¶)( �˜ßùãWŸý<{™¢LSÛqÂ;j‡9»94ž5NžP’E‚{W{ ‚ Ë&@¶k	%×Ì²
{ÛD‹jK˜¿EXtž' N2XOZÃ�žþtX‡ÇùR�ÏUîks¼Êí™Á©}à!8* � Fo>nÊfÖ«	h
mÿjßU£+3È,t¢,ÊØ^X*HV¦ÊÍêšÁË! h ´ é CKk#,s6ŠÖóüdktWZ	ô	ÀRb¥ëÎÔRC´. 7 – „½ÿVÎ+œ¨ƒ…Â"|ªýi(*\1DFHJ}­ë%=?AFfh•½fc# X k ˜ ¦ ô *ÉÒ¾&|HA	ú	<
Œk¦õkÅ7¼L/)‹È-G# Û :“	Bc�é+‡çöd‚�–?‹ý'žnØäb”
V'  Î ±z}Sb¹‡\_ƒ¾Ø@c~6ÉúK¯<?J7Ûâ0TºZ§‡ñô6 /D¿ÁËæ·pÐ@EOV‚e2<‰¬¶Ù&Ad£¾á™à^ƒ±^‡QXðµ(SÔþe{Ž„ b 	ó¯å:£©<Wë«$¿ÿ8•U·—æ£çïüp% \ „®ÆÌ	Ô
ö
3ŸÅ`h¤k( d×¦~�Ù3MTr²+	R	Ã	CvÐÄ–ð
h�,B`.6N†¸ <E 6è�–î-z
lìÿMz^ø6t³ñ/3¼  †`ªÜ1I	É
¡÷YÀÓH™²>Zó²Â­ %,C	OÇRY…¨]� ì µôÀ‹¬¾�J½	§
ï
Aè˜@C ñmòc2 (­ºup&µ!+ü3¡  Î]	Ð	o
ÛìÒ�W•Ô~jå& ¢ ¾Ç›»ú:i¢M	ì	3`ún7~Í÷GLÄÉ""n®[]ŠÜ4, 4 š ­ À �¸ºÔ]•=(8Jd„~9CÆ	ª=£rÛÄ/Š¬ê(®Î¹9Õ²Èç Z € ² ç ”áa|·ÁF�i	¨×�ÒNH—5ÆQ È Ñ ¢òðAí
UIì •7÷ Ó ö `µÇR©•	ü
	nÅpÀ/fô3 Å ð !¤ŒÇDâQöñ	Ñ
LWÌm«ÇØ1:Êñ0f = Sù>%£~ò
ÍK÷9e�¸9¾ÐÞyp¯! ÛoÃ�´}	3	$³Zm³™õ¯Í#Â C¿øŠ	7
¼
±)KŽ¨Èä/IÅ O ¨ Ê �ÃËz_joíü	®iæ9'�–9ñô m sÛûYÊäò¬>
„SŽøOë-£NŽ°:â T $ÿç	+
«
ã
Ç.DCî>ÛÜ?qù ¸ b‘fé›
¾Ð×Ü%©(á	µ	1P8  : œ¢·ðMÝ©×îx�
ÊKÿ)�Ev6c­ãÿ u à ã +.Bh•¶¿63ÖÙ‘A hp$Q`x–· J ‰ DŸ	à	\
þ
E™±ø hx—ìü†(Kƒ�*¤Ô àe›C®Ürvn	Û
<ˆ‘¼:b0Ÿ9¶>Q$|öÒ# <AGåóúWê) þ=£'Ã=yk:ƒ¯îOŸ‡²“‰ s)6% Ý ™ÝÉäTìX¦šMTŸýÝ …�`Ç*36«#€À.Xdú{œ ŽŠ™ß§à|‹ë	»	5pÙõ±Fƒ“|­Ú-hŽ 'uì#%l	 
¢
 ûwHI©k™ÀÂ«' 1 ƒ ø «ºAˆÐy½]s
†
&³„pÜAŒ¸mûŸºXÛ( $ ' xÒ‡•«Í-$
È�Íb|�E!:fåéP-FöYu™i€ÖÙ5 {Ì[Sh·¯A
[„Ø˜”b¸´ó¬L(  Jx%‰Žâ		
Á
oµOuzÈƒðRJ×w�6bt€½{~"9é-( Ov·þP[wÄŸç-ÿ»¤
Ìú·V>S‘»ÐVkÝïš$t‚ærÂÓ X`5Ôé‘Éœ	/vYˆ½ýylËî›ª²á Õ 2 3Yk—´/
£fB­"ç=ñÂÖÄŸ[ … GŽË’¿¬	u
ˆ
(¤ÉruËÙŽYIë›ÌÌ ž  p®?oFg–YV k¹	3�ÉÞëÄ+W Ë„Â‡ �(ƒ£b_šŸŒbú ú 	ÃÒø×i
˜¹n™ÌàéV¤,4Î--eá§\ÎÝ t7×eué
,{3ºÝ2=¡ä=Z/ ½ ¦Ll(-|»‹¯al†™X_Ž	õ	`es}’Á†¦ì¼ÏÕpSý©‰¼lxƒµö`hu i µ ò AD$¼Ud8o…À?	$¡SÃDTdäV4aC ~ ê ³_“ôý²{[	Ï
JŒ&cLÆ”ï 8 W�KR$†—8ÖøM�j~ŠÉìizJ¾W / g — )jÈ É%‰j{Õó	‚„ôQühjs)+»0CEGIK|êQ<>@BGg(¼³6  9|¾ÀÏä[^¨èædõVc�#}€•«µcà˜þ]ŠT]†®&>–�S¹ã¦´î“ðý	dó …çc
­,S©0*	H	y
È
Ó
õ
kBÃŒ2±ÄA_g  +¿ŠIB	NÚ¹o´*\2 3 Y ™ Ç Ð æ Óù<'}2T§FÃ€­mM¸P õ = nÆClö8ŒÄËlªÆ8½x09o ÉÌó l § #Ên¾÷û	6
=
ƒ�hå¢ÚŒ.H% t C�€èg”5°Ï÷'2Õ�@~Ÿþ(ëDo#'J5w•âO7& Ü ;@FäÞéd¦¥ßB­êÚ
<žüaØ‚®_2=†"Ÿ¿Ùcù›Ñ�( # & wzÑ†”ª
¹‡Ï,Çƒa—ƒ GaŒ·H³«úõWhØ 1W_Ó$,Èˆ�á›	Ëe¶j<sÕz�±åž '‘˜¸2€êaà[ƒ†% ²~'Tcº®`…˜„¿+_drzoK SÜã1U¨ˆ`kw‚“õ+ {$ˆJQZ]i§ç/G	Ç
ô
A7Ub‹”ûLi{‰°=@yœR»â¥íV’ï ²  Ï <øm5
‚ÙEgÂä7ÃÊ©l8³[Oò/ " 0EV…è¸†ÒA#àfÆÊû4­‚ÿFi�`¶<G}…ž!rÔyI�øg~áN! ÷&lPY„—^q6TaŠ·DfÁãÂ~é`hˆßR›ìUÿ’…j ! E ()X]^_`abgûü„±²ÌÍçÑ !"WXƒ–¤	¥	ÂÃÄÅ3]pS_`uv'(BCe€�¤¥¿Àâüýþ !;<=>ghšáâã_„�²³´µ;_{|‚ƒ„�£ËÐÑÒÓHTf|}��‘KLM: ) F *Ychý‰¢­³ÀÂÎqF¸Ìž¦	
I
b
’û=ÏwÚ)¦"?›äV…�¤ÀélzÌYñ/¶)Õ  p °	Q
�
�
‡>¬%r�ÐM†‘VÒm{ç0èÖq% 
ÁH³
PÄ“ü»k¼Àdx *|§å<–õ“¥à#ÒZòÙý&( G UZdi—£®´ÃôræG¤ªÍJ
c
9Xù#@œ 9WZ¦Áç˜Íe*0 * ? c +Ôþ26Š�¦Ï ;¹=Ÿòø§	
&
w{‹ì®dqÏÛ¡º·êú¸Î¤•·ðÛ ] …¥Ç		R
‚
ˆ6€&Rs!ÒÓ|õè™¥l ëÓáÍ	?þ ÄÜx’äì%U q ÎŽš±	
Œ
Õ
\Ž”±‡iÆna1i€±é×  j¯±áü	�
÷
.­4L\ÀÑNW)sr ! Iñ\ÃÐ,	S	Ù	}
´
”R¤¼lÁŽD”Ó×áÏþO‡!'% eÂØ0§œ0NUs³5	Ô	ïDw_ñey+¨æö¦áú/ó7TÚ¹F  Ù ‘‚Ú14f
9kÑý:—½)iœ}=	-CåŒ 8Å7“ 	1	Ä	m
&QÅÅ>—$a¬®[Ú=ã H µU—sçmtYù7u´°4‘¶NfO+ 7Ä]”õ{ò$O–[f›ºÂ„�èžÄ+  C V[e]‚¤¯õH�¥«¶åðØ
:œ N]¹‹´Ö_oú0]Ÿ:X§‘™½Îø x jln}é˜qƒï.Î
K
d
{
í†9šA[�dq + ‡…Ý<2ó±	'
C
Ê
¢|Œíæ³ÐvrëûÃ¥! ,Õ7Ý8!a> J	¨	”
ß
µÔ‘¯;[¢µ¹kl¸Üî   @ d ÿ3‹§ðÐ«º ù!
øZxˆÚIš?rC¸¦Ï÷– z pžs¹

M
žÁßL`eÜ»ô³ ñ®  - ^ >¦ÓS
	ïs�ÈSæÙ¿Ååïö‘Å Œ †³P9
‰âíÊüI£Ô£¾Å¥m   &Ý	'	<	D	ƒ
Ì
æ
,¼	~
7¡ãÓSQt}†©éßš$à -ìúÈ	 	P¤Ú‡õ'tª"GEZ	}^¦› ÔÐK#	¾	·™D}µy˜×åó
dÇV§% í ìõEŒBžã	¨
Ê+­ï@|kÝ0àòZnÑþíýíH ž¼ ­éhrŠÿÅÊ¡ø“Ù§&'‚A ¶#zÁ¿âÎ	ê	)
º
ð
«BA¡3 ²
Z
MŽ»•T8d",+�ý4¢ Á
äŒ	ó�öqˆvÇ]b¶2²;^í r uÏ›‹	™	¢	
�
±
)®4QxÀ0jyçxê�^u �6ßÖ
iÝ,]P�v’²�'‚oÕßjØ	 'ÏÑ—	Üí2qÅ{¨ÒX–Õ¾tvÝsëÿ K‰²ð^	Þ…ÔX*’1K/0  k‡)â4�›íõý			Ñ	
2
_
p
‘
¾
q³Ç/OwÓÁÒhªò!`žÝLš­÷€ÉÑæ  L°Õ³	E
Ã
ø
¦®±è5M] OŽêkü
! ûÄÑT	`	…	í	þ	œ#.å%8ÂÎ�Ø^P"(*  £ ª È×œ;åò´]N	Ú	4ÕàGS“HMÅÊ#E#•Ë‚„‹”Ýÿn5 9J£#y¢~
a•ûo]m¹&Xov‰¢ÐÞ" ¿¼jé/·-	z	µ
Ò·Ö¥½ñüY›øÔœ¯â\@Õˆ, ® Á fÃÍßê1O¨l÷13Õ	–
Îð`´*¤ò+‡Açñ÷Ïèô†�=èG×/ Q ‘¹:v|–�Æ9Vet6	r	}	Ç	§«E>ÜÅ,0‹©­ë)0§â:º³ÉÑÛ©º  5 › Ì ‹x»Õ>M)K…´:xþÀSXfz¯BZûºÈÖU˜ M QÅ#Ù^]6OÈDÌá
GöÐsUk“Òè08nÄ1 � MâÛÂ¡Úýj	:º8W�O»D˜t W ³ è ƒÑm 5ÕòûGVª	g
lþ*j©¤Ó].)Ç' Ú .’bRa¸‚½;ª¾ˆØ@~½ß>‚¶;I6PmaæR�$ [ 5•}€ƒØ2qÂ	Ò2˜±
	]÷.ò
_M; ón
¦
î
'—Æ?Ÿ%b ä ñ¹“9Icï8@B€L	Å	ëù}Ö!–­68\‰Û3ö Ò  £Æ”	2	û
VJm·˜×ôð/e É €Âñ°RÆJíÇ=ê,&¯>óø I a¶Öež	
š
ý

µ½$Égwûg´P0_Ó ÜòV‰˜ÈSëš	º	x�Ü„œôí8µ°Æ±’¬,gõ ÷ ZªtëÌ¼"®#
@
r
Ÿ
Zúvo @¨ä·O4  Ô u¶ýèæ–º		.
À
nu¢´yA‚¬ïQ=ºÖ5ðqÁè, ÿ �­E‚•÷XU£ÍÈÃžŸË } ¼ ñ ¥^7nzI|# %»2<ÅãBgt$  f 8bÇ	¿ÈãRò	Ò
–ÕbßóP—\gœº/…éP;ò Æ "ÿmÅ;½ö1MS‹n¬ÙË1# ?^©ãÝ¤+¬Ù
;�Î1`Ôµ×`^²ª¾C€°ù"ôŒ &­I�¦æ4
Æ
ó
1¨nzÿ²N‚±)   D 'W\fúƒ¡°ö
·Ë�H
a
ú\^útû:EfŽ:œ¿Þ kqšÊÏ)  > o T15¥Gñ÷P
†OÃzŠºŒ­Lcjpÿ{ø ¹;Y’ÑßùÍÑØ ê�™Òû		
[K[¿Ã °hr˜°$ Ø ~/Äð/[Ï6~’ÿ0	4	Ó	e
l
|
î%Q›ùÎä‹  
 B kmp\“Žµäôï
s›¸Š8nN\žeš¯��NÃ y oÜï7r„°	
 
L
“
‡�´:B´¥öŸ , ²=ùO8
Ë
å
£}Ùáô©ìFÉåûHs¢ÄÄÞš "Dé	(
¹
ªÉ*î´/ß÷ìüØ¦GŸÆ� t5ÀÞ‹	°
Lh��O‘wÔ] ˆ†Ôï3šô–	²	1
D
½
²¥1ÄN°çÿg§Ñ½‘0Jûþ  © Ö8"¡¶y	„	ý	~¶ÕFð’\š%�¡mÝ! P Ë ÄÌÞ9Nu{kÇ2Ë•
à
ýFõ³ÏR@jçÇmŽ¹— V -4‚×`p©	©7°\£µº:(l:# Hbî?K	ú
¯êøž<é¶óï.òõ tñüËå»!d­¹	

"
-
?
�¡¼#Ûfƒ›@îPì¯?§ e | þ ¼mHT¢¹.O;As"  n & 04 ¨Ü¬G
O
Å
…ù[Ây‰ù_bsDÐÝj±ó° 	 A × ŒîÑ[Z
óú
œJ¯7¤ø�—ã s™è	¯
¸
ä
©È0ÃàMEf�Þ¼ö¡ÓÝF€ú U tGÆüEôE¨ïQ$?´Æ- { ý %Ÿ»¸		

,
N
»"¡‚aíÜiò¯@r qrº µ	¶	·	

¬
­
®
¨û/Ÿ ÂD�DìÝõE~  -\  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                           %                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
                                        	                                                                                                                   
                                                                                            $                
                                                                       #                                         	                                          
      
            	                     	         /                                                         	      	                                                          !      &   +                  s         (            %   f                                                                                                                                                                      %                                                                                                                                                                                                                                                                                                                  
                	                                           
                                  $      
                           #               	                
  
    	       	   /                   	  	                    !  & +      s   (    % f   ~…  {  ‹  ±  ƒk  ‡ñ  ŽQÏ	ÌÍp/V p
Ëy	‹	1
H©ÈÉû¡¢ÂÛû¡Æ†úåœqP‘à³(ÈX`v»	"IüÖ›“xèñ( c�ã&	˜	Ô›g"-€õû†�ñÕP	“D�»Ö "@"mBˆ¥2Š’Êì6$Ñ6$6$6$6$� 2t„	#úm"óÁë¼Áœ‘š½�;î·‰ãø�f\óL»"ß øˆi²(àz'Ãƒ-sûäO"äiÅèY3N$	„ ÂìÈõ—EBµ>C€¡îÒnyVx±Gºj’Ñ Û*è}i^œÛ˜«õ€ i	%4£
¼z#†š£
#Ò}Sbƒ¾âT¢>�£
Ä!#Ã—ÚD¸~B{—b
èž×�LüV:
¤`/$÷ Èæ¼r
1oë]
è^œÛ˜«õÇÏÚi‡	®	ù&uÅèÍYnzÉ´¬Ù
`//Ó	îAv �¹o´ *2d	
»¼"#¢D—7
Ê
|ÈrÃŠLAøØó¨™&ßôöìEï™
³vÒ¶ì	º
EéAo¥4�D£
¸~¼zÄ!#†šÃB{1 9œC€ i	(z'¢
 ï¸Šnžˆ LéÏ&*ü ˜µ"	x	�	Í ¶îØó)-VZv|¾™S	ú™ÄÒ€ LÁüi	V—o´ ^ÚêõKW¾F<qÉ&2Ò ”„—^qŠ ±	C
æeVxÉ±G´ºj’ÑÒèuOž ¥ÞààK0 (¥Þkàz£
Á}"#l'bíþ5] ÕéðÓ”«¥R
Ø
:œï9_€Ú>‘šÖœ]æÂCa½ÃžOûÖ'
ß
l4Øó™†é·½
²â Òæ·à/Ò/¬Ó	Ù
î`¼Í{[bž(Äí=	6Òè1 Am	Ì”ï”ÂžÚêKÎî* _Û öX¿G=Ád„	ý	

¼#fw |‚…™ZcpOf¥¯è.¹
		¿
 Ñ³xûX�«<¹Õï›?Ôç+ ùž¿ù'ätgÿi+, =ä
àEå¡ÄÝ.~‡qyQÅ®=ù'ätiè. ÑûX›?Ô¹
		¿
³x�«<¹Õïç+4×p°\:Þ š§„(,OY]4gN\Óèëî.¹
			•	0
¿
 Ñ¤³x†¯ûþX�¦«D<¹Õï›?|�Ôçý+, =d„	ý	

ä
¼#àfEå¡ÄÝÁ	1	ö-ñ^L1Y�s†ÆíÀ¨|7`µü
	/8"¡~\%¡Ýy�¿CÒ˜±ò
ð[Ï|
QÎš�8µõ&
¸ÞK_ö %¢©¿C	Š	`KŽúnnRn…¨3ðš[�Ï|
�Q8µ12<Î‚ãõJmÐÒ ”	û
mÏ	}iÜ+Ž�Þ™0ÃMf¼ú ÒîrØ¾äîÄa ¤òÂ®ŒÄ	P	Ü
êI};4r±ï²7”¢}®ûÁëßÎ	«,APv’'U—…ñ\Ù	'
ˆíR³7´D”°Óëû‘¥þ+ln  04O
…Ây‰bÐcm†8¯;;7’Š±Î
�‹=ok«­âîžX×ˆ[óæ®UoƒT‘´ ¤ðN¹‹oŸ:X‘Ü
I;}ëÂŒ	²®Á7Š=o«­âa ¤ò®ÄP	ê}4r±ï7”¢ûÓëî	•	0
¤†¯þ¦D|�ýÒ J”	û
mmÐùŸý<¢Âj9Nž’ü¼ |<ÝŒv'ÏÑ—	Üí2qÅ{¨ÒX–Õ¾tvÝsëÿˆ†Ôï3šô–	²	1
D
½
²¥1ÄN°çÿg§Ñ½‘0Jûþ ‹ ëÒÜ	&	;	+»îr	† âD¢ØP¾½äî|¤#Äß2 å B‰¸w¡n·ÚÅáý-½é9€5x¸.	
j
˜
™¶€;¸Ôfâ�°¨ÈAÖL]‰ŠJK&(�Ðì	
^
Â
pÝpÆvz„©éñÓ _�ÜK™¬öuÜÈÐê 	.ÿ �­E‚•÷XU£ÍÈÃžŸË í_Û ëöþLX¿ÏG•žï=+-ÁB .íÉw	‚	”	FŸÀùö˜Fg ��+, ²=ùO8
Ë
å
£}Ùáô©ìFÉåûHs¢ÄÄÞš� MâÛÂ¡Úýj	:º8W�O»D˜t º û 
Ú.Åáìý-«½EÒé9€˜EÄí05Mbx¸É	.	w	‚	”	®	
j
˜
�
¶
FQ|™”Ÿ²¹Àù š×ò¦¶Íòödu«êýZ€˜œ¥ù-5F;¸‰­Ôfâg�°Ñùý¨È A~�LÖCL]‰�+|Š˜*8 W g � — ³ è Mƒ)jÈÑâ WmÉÛ 5Â%‰�¡ÕòûKRj{ÕÚýGVj	ª	ó	g
$:‚„†—8lºþÖ8Wø*j�©ôQ¤üMhjs�Ó)+»0CEGIKO]j|~Š»Éêì.DQ˜)<>@BGgiz(J¼¾tÇW ³(­ºup&µ!+ü3¡Ov·þP[wÄŸç-ÿ»¤
Ìú·V>S‘»ÐVkÝïš$t‚ærÂÓÍ °Cy¶Ž?†9D�¢*;†b%¢J°üáåW×ïÓUoz	 A × ŒîÑ[Z
óú
œJ¯7¤ø�—ãŽ áßô÷–ÝÙÜ	 ’Ìšàeý
�A§W²~'Tcº®`…˜„¿+_drzoK SÜã1U¨ˆ`kw‚“õm † ÚsÅáý-€½Û™éû9€YÊä5“ÀÅÒÞòx¬¸.	Ý	
>
j
v
‰
˜
!„™(SŽ­ø$¶ºæ-u€ÏOë;¸s}Ôpáf&-—£âNŽ�°¨°µÈ!+A_:ÖâL]¨ì‰ü3XŠ¡ëÓáÍ	?þ ÄÜx’äì%U  &Y     ²  ?        ?Â0>ë9§=êŠ*ð"u˜¾ê¸5õgl¾eŸ¬ »ùv$ Á FgYF}Ge€åuwÖ�ãí¡‚	Ùqyg‰?‘èdöÛfÅ*Þª½¨öæ…%–C65ëªêª®«»¿òŠ.ßfóXuUa�GyPUZ\uGMõÑ‹(¯Dá„nÅ7q^ªúúÚÜÝç»–\&púúô§¡j•UJŽ.ŽmI•‘øÖš[ª*û-¢»+úºú*ê®7Y«S™õ6uµïS¡MO¾Sž.¹±u61š�•Sµ#½QUñHÏR.]x‹9îýWÕBï8yváÑHÔ9Óš¹áª¾ÄQú†¨U�®§A™TÚ)tj'Q–!eF<·FFƒ­ G†cî]¡6E”ŒvÛlD’]PµGJ&Ï¨–qíæ@ÄóÛ`A4S†íAøÙ†+IÝlÔö·�$¸Š*ƒH¬ÂÑÂÁ3ÍUâ50¿>wÝVqöhvÇÔª½Ti%tç+X¸àuò7¿…éZ§á�¥Wõˆ…cXç5UcŽéRJôDi†TXÓ®‡VþS!f¯Ek×Z¨4QUPŠ-Z¥òÇãL<Ùy6_ú û•Àº
ª3:4õ9kÀÅ«¦˜j¦šVR™UVR&uj•!î�ªUÅZé®„—º¾$-
:»BdØBÎé¡÷~çÃcS Ém‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I~æãÏñÊ1?€úßÅè  TW02h?Ö »ltHôþñÌ©…ÕÇõß#*šâê¦�-“0+ëÂh»ëÈ«JO¿ù^ôØFÿ3�ÛÓÃ/ÁWñO×êÙ0Â±[²4(³ °¶¬_ôKó´Q{-EdPÆ3Œ[0Æ|•7SOÚÏ=NëMfÜ	=s˜¾0¼÷Ot±…½L=ª÷Øf°ÔÐÛ=„·Fû<°6;>„ø1t¬83þî²ôm¾GÃ¯or;;Æ*Î‚BOÔÉ�<óhÛOa�ž®ÃA5Fo�ðÞ³õ“OKúüëHuËtã5ÏË ô÷<Î>Ë£JÚÐ7ÁÐ°ºUÀÏøÎ<pÃmO.(�ÒÙ<Y>ïS_Œ�onŠÖÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß…Å6â:Ú¢EÕX×19j­]Qn�ª�Ec\ÅLæ©õÅâ:Ú¨•uV5ÌDÎZ«WT[„ãj§EÑX×19ª}uE¹žºª+�U�¿3š«—TÛ¤iêªï¨Œîe�.èeê£x�¼¥
E9ê¹ªî½•U>÷¯Ì©á§“ã6ªµPÛüišæ|bŒÙê!tT†L¡†ºÚEZap«®j‹¹™ç&AX©Ú¬š*±­îad®žuª¨¹Q%žDevUX‘¤cRµÅBB™�“tFfMQê„Ö* S	¬Öj’NÊt¼#* ª¡R2ëDÎ¨*µS;…+æz¹d¬AzÕ2¯q3¯c\Äã7gNÞ+rÍù›ŒŠ>&ffvEÃdŒŠ˜éXÉé˜Ëš˜�aP’äŸ¾!šoÚö0	²c¯­7ŸêN+™Ž=ïµ i.ÛëXæÚ¾¡šÙåöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„HßdmqÚy™™fAM©d]6Éfb'¨Ò˜sÑƒI QšêhUdè·éÉÖèoêºª�QikTU@õ6‚hMÈIœ†”ÝÕ:˜¸¦–­Ð’¸/h!R£�tCÍ#¹ñŽŽi˜ˆýdTEÖ‡ð¦�AV­K¢U6eVJÐÞñYè(2*Ém~PAŠ îXiÃhfË×��K ÔYõ¾Â£ÒšUÉ«ÕG�vyí#N·E~ÚÊšþŠ†´SBÐ…ê� ^Æ®�CQüTéÚ¦)8 xsÑV(!ŒéV¦‚(bS"u`‰T{—U“V¬µV9Ed)§„’jjRh¨�èñ¹Œ"Ÿ7F2PEYómh”ÊYª)V³)Z¨¥m;j©}d<VÃU¿¦VÕE‘ñ„Š+Ò ]D½æ• {×-P1UòæÐ1ƒ÷œ…ößåµ*¨Ä#ÉSy[þTÿÆ¤N‡ TðÅÈ1ELT985"L-Î3%÷Ýüó:XÏ9Ð3/k=­3^(        Ô  >  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ’<?xml version="1.0"?><Features nextValidID="15"><Feature recentID="14" name="MP10" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1287-1748" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="13" name="2Î¼ ori" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4587-5929" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast 2Î¼ plasmid origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="Kan" directionality="2" translationMW="28979.67" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3661-4455" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="ADH1 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="30-734" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for&amp;nbsp;alcohol dehydrogenase 1&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="TRP1" directionality="1" translationMW="24145.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="6470-7144" color="#ff7f50" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast auxotrophic marker&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae TRP1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;phosphoribosylanthranilate isomerase, required for tryptophan biosynthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2465-3053" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7247-7702" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="GAL4 DNA binding domain" directionality="1" translationMW="16868.03" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1748" maxFusedRunOn="1748"><Segment range="762-1202" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Saccharomyces cerevisiae GAL4&lt;/i&gt;&amp;nbsp;(truncated)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;DNA binding domain of the GAL4 transcriptional activator&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="TRP1 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6188-6469" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae TRP1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ADH1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1852-2039" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for the &lt;i&gt;S. cerevisiae&lt;/i&gt; alcohol dehydrogenase 1 (&lt;i&gt;ADH1&lt;/i&gt;) gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4456-4560" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="T7 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1778-1825" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="HSV TK poly(A) signal" type="polyA_signal" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3382-3429" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Myc" directionality="1" translationMW="1203.34" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1748" maxFusedRunOn="1748" detectionMode="exactProteinMatch"><Segment range="1251-1280" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Myc (human c-Myc proto-oncogene) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1213-1231" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>c9f3c673-5a34-4172-ae42-71550b0d3379</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="2:53:36">2018.6.20</Created>
<LastModified UTC="7:8:14">2021.6.18</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  $˜      <  ‡        ‡Â0>ë9§=êŠ*ð"u˜¾ê¸5õgl¾eŸ¬ »ùv$ Á FgYF}Ge€åuwÖ�ãí¡‚	Ùqyg‰?‘èdöÛfÅ*Þª½¨öæ…%–C65ëªêª®«»¿òŠ.ßfóXuUa�GyPUZ\uGMõÑ‹(¯Dá„nÅ7q^ªúúÚÜÝç»–\&púúô§¡j•UJŽ.ŽmI•‘øÖš[ª*û-¢»+úºú*ê®7Y«S™õ6uµïS¡MO¾Sž.¹±u61š�•Sµ#½QUñHÏR.]x‹9îýWÕBï8yváÑHÔ9Óš¹áª¾ÄQú†¨U�®§A™TÚ)tj'Q–!eF<·FFƒ­ G†cî]¡6E”ŒvÛlD’]PµGJ&Ï¨–qíæ@ÄóÛ`A4S†íAøÙƒØñkðòÇãL<Ùy6_ú û•Àº
ª3:4õ9kÀÅ«¦˜j¦šVR™UVR&uj•!î�ªUÅZé®„—º¾$-
:»BdØBÎé¡÷~çÃcS Ém‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I~æãÏñÊ1?€úßÅè  TW02h?Ö »ltHôþñÌ©…ÕÇõß#*šâê¦�-“0+ëÂh»ëÈ«JO¿ù^ôØFÿ3�ÛÓÃ/ÁWñO×êÙ0Â±[²4(³ °¶¬_ôKó´Q{-EdPÆ3Œ[0Æ|•7SOÚÏ=NëMfÜ	=s˜¾0¼÷Ot±…½L=ª÷Øf°ÔÐÛ=„·Fû<°6;>„ø1t¬83þî²ôm¾GÃ¯or;;Æ*Î‚BOÔÉ�<óhÛOa�ž®ÃA5Fo�ðÞ³õ“OKúüëHuËtã5ÏË ô÷<Î>Ë£JÚÐ7ÁÐ°ºUÀÏøÎ<pÃmO.(�ÒÙ<Y>ïS_Œ�onŠÖÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß…Å6â:Ú¢EÕX×19j­]Qn�ª�Ec\ÅLæ©õÅâ:Ú¨•uV5ÌDÎZ«WT[„ãj§EÑX×19ª}uE¹žºª+�U�¿3š«—TÛ¤iêªï¨Œîe�.èeê£x�¼¥
E9ê¹ªî½•U>÷¯Ì©á§“ã6ªµPÛüišæ|bŒÙê!tT†L¡†ºÚEZap«®j‹¹™ç&AX©Ú¬š*±­îad®žuª¨¹Q%žDevUX‘¤cRµÅBB™�“tFfMQê„Ö* S	¬Öj’NÊt¼#* ª¡R2ëDÎ¨*µS;…+æz¹d¬AzÕ2¯q3¯c\Äã7gNÞ+rÍù›ŒŠ>&ffvEÃdŒŠ˜éXÉé˜Ëš˜�aP’äŸ¾!šoÚö0	²c¯­7ŸêN+™Ž=ïµ i.ÛëXæÚ¾¡šÙåöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„HßdmqÚy™™fAM©d]6Éfb'¨Ò˜sÑƒI QšêhUdè·éÉÖèoêºª�QikTU@õ6‚hMÈIœ†”ÝÕ:˜¸¦–­Ð’¸/h!R£�tCÍ#¹ñŽŽi˜ˆýdTEÖ‡ð¦�AV­K¢U6eVJÐÞñYè(2*Ém~PAŠ îXiÃhfË×��K ÔYõ¾Â£ÒšUÉ«ÕG�vyí#N·E~ÚÊšþŠ†´SBÐ…ê� ^Æ®�CQüTéÚ¦)8 xsÑV(!ŒéV¦‚(bS"u`‰T{—U“V¬µV9Ed)§„’jjRh¨�èñ¹Œ"Ÿ7F2PEYómh”ÊYª)V³)Z¨¥m;j©}d<VÃU¿¦VÕE‘ñ„Š+Ò ]D½æ• {×-P1UòæÐ1ƒ÷œ…ößåµ*¨Ä#ÉSy[þTÿÆ¤N‡ TðÅÈ1ELT985"L-Î3%÷Ýüó:XÏ9Ð3/k=­3^(      †  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  G<?xml version="1.0"?><Features nextValidID="14"><Feature recentID="13" name="2Î¼ ori" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4147-5489" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast 2Î¼ plasmid origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="Kan" directionality="2" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3221-4015" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="ADH1 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="30-734" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for&amp;nbsp;alcohol dehydrogenase 1&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="TRP1" directionality="1" translationMW="24145.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="6030-6704" color="#ff7f50" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast auxotrophic marker&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae TRP1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;phosphoribosylanthranilate isomerase, required for tryptophan biosynthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2025-2613" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6807-7262" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="GAL4 DNA binding domain" directionality="1" translationMW="16868.03" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1337" maxFusedRunOn="1337"><Segment range="762-1202" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Saccharomyces cerevisiae GAL4&lt;/i&gt;&amp;nbsp;(truncated)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;DNA binding domain of the GAL4 transcriptional activator&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="TRP1 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5748-6029" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae TRP1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ADH1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1412-1599" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for the &lt;i&gt;S. cerevisiae&lt;/i&gt; alcohol dehydrogenase 1 (&lt;i&gt;ADH1&lt;/i&gt;) gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4016-4120" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="T7 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1338-1385" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="HSV TK poly(A) signal" type="polyA_signal" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2942-2989" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="Myc" directionality="1" translationMW="1203.34" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1337" maxFusedRunOn="1337" detectionMode="exactProteinMatch"><Segment range="1251-1280" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Myc (human c-Myc proto-oncogene) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1213-1231" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>c9f3c673-5a34-4172-ae42-71550b0d3379</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="2:53:36">2018.6.20</Created>
<LastModified UTC="7:7:31">2021.6.18</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  ˜ý7zXZ  æÖ´F !   t/å£à;#V] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÔý?8]‹ vG˜ˆkÝøZÁ¯erCm•+Ày—õùjô™‹Þ'5 R@3#jo5Å	ï–6þƒ�by½fµ&JË ?öâ!Wq5›jŒj Šÿ9æj…¬q-ÅO[£àrNÚ“{ú{×fî©…Ü3™g¢¬ýuìzuh½-hÎ}éÃÈmÜ\VÚîÚ4ìÅˆa0'çC®4�»`sS=~w8¼2?gù(õ}¤zè·ogç�ï‹ÅYýs<¢…êsMn~ ÿ¶Oáp�L_¤Îÿë¦Ó?öy©_Œ]SeÉXø ~#ï¯µr§\:š~5ÔÜR£ÍöQšyì�¼4çzÎµ•‘˜`³j0ëgÂ|¢Å­ç.t‚ƒG8­¢%Ùˆ2;Äìxïmz%ÝÕ\yjÊ^Wz0jdí+Á^|Àn¨o’²±úÙYvM-,,qbÀTVºåú`kº´Ìø¢rŽ2ºÕBRZÔïÌ¾ÔïG’´¨8xÉé�¼D~±™™ þÛ"‰QAÒx&E=o¶‚u­Ðö1nÀ››EÚZzìíŽ_™ÎrŠ†¹ø²–ë­¡º¦åõÚ~wÄã‘y—NTÕ8Ø_"o}Ry×åëÉp K§01<fÛw—ª³�èb¦Z>A…öJa°Ç¥lCÆgiÄŸ.í—XÍƒ›Z9å~NÒ@Ü—ôX$º¿ÌÀ1™D•m%2áL.é,ùó“Ù¤!·X#WÊ‡2»æ÷ù×|£‚¦m[‘÷5'P °U%KSQú;ÏãqŽä–Ðˆp!û±Õ°�Uiðp=©Mî¥ƒiö¡õ×K+"©Á…Z´Dš`'-ÍT+©"€(™GÛÏˆ÷ Ú×’›aây°™…v…';ÑÀ<óòB‚'¦î§,>ºš¤Êtóhœ'HTír!t ý”qj8³™µp¦@ €“…å ù{_Ò]÷ænûmƒÈŸ�n¿ó7� @_Žxw¹Nöu"Ÿj•g L3z“Dd=×¼*…‘¢+ãsÕyÂ”÷Ëá]¨=7‘µˆ=˜ƒDr¾ÊÍçQ(œÅZë…yA"Pl~Ú!�º_!ókgªP"©¥I‡¿Œt*¸çè#R¯cÆ�~œ2Šdz6Ch†þYi1“:ÁUl+ÎŸý}Ç6ioZ½. Uô8çÞž{c†•OÓœ¾3ëßU«µ…ÁXh ç‡6pÀhï—an;ReË‡S ªæ¿¢U&îŽžŸ˜„«2í. x^Lg¿òlþñ$–4„@&±p3sÞhBnÂ•B~Y[ÑCÄ•®t§¶Êfk³üåÛ¤iË¦¤©
ØšöŸ>FrÜ"ñ[w‚à?…º¤�äÝ õÏ^Êî8€¥–aÕ”¡÷rÏâ%yñï„×<4û¨†Í	�‰ù�3‡%Ï#¾5š9Êò!Gg7¼¦˜ �­\9sÑ\75½þÑn)æ"êhÐÛÎµÂ¾bóÈFEŒ4�àD¼Ño›G+8ÈöcÈAWJ¹âö�>vêol¼™‹ECßàƒg9›&{ÎûÀ¾KÃuêí¡½áÌÈ ,2Õ×t—.x÷Šm�iØ<µ^Q‹¥]~Q2ÐÒ´à b�wÚ`©§ì$¿ëæÖkŠ·CãË;*yJ�Du>²Ó[žŽ•¢ÇŸÑ®ÈÛq¸´à¼ÿ:«Éê¾çnj9½ö…® ‚7MÜª�…e¢šÞŸMF=¥ß¦oj§ŽåæˆÕ»óµ°ÒÐ©�ÿ—¡Ž.V‚è!ßÙ^%KvaIp�ˆ2ûaz<?	#È.yÚÉtQî !Æß„o@Òåùtaf9\ROGpyÄtð’ò;µ–½o’~ÈD^B7q¬…!˜x¿˜Œ¾ÔÛ}Õ'úHž�	—ƒÙ�<Ïä³ÎÃõµ�¹%9ã‘MrÀóÚ}îô”â·ò•�Rm£3rÓW¼F]\#âÂ$#�žñZ ÀÝºã[‘
ØX_ã¥:dÍÊ>G°Ò�UZ¯¥~eÌ·à}�ÆcÚÞ”»Nç@œýLšú£ç0×ä)Tò†ª¹Éè×<–\)—ßÙ�Žà‚Ž7ÍOo�µ‹Æ5~÷.né?Ÿ¿ocž;Ì(”ï¾‡™¸ÝÌ¶DPöóM:4A
íè…Ø«�ªxQh£rù±+8	Üh¾EršÍ¼ ÛF¼¤{5‡�NóÓ—‹	-ÕÏDc¿I|Ñhõ˜¼˜lŽêziTzd 1ÍlJŠ”(º=?Ç%)úïBþwºªÜ-Ø ¢Òë˜3�ã�P|.6W‡îH¼(ñ9O¥ƒŽã®Ôððààù!X
í¶Ÿõgd–“O“UQƒö7˜Ìzµ·
¶©ÉUpN¤ SÑi0³Ž!_-¡E2˜"…Ç!}°™sÇ™,ªûWïïZf.Y¸?u.W™×]*È iMÁ_‘
_"?¦Ð-û÷%™�—mbi`R�3Æ h!°»� ›³ ¦À3Ê‡§AÚ©˜‰ç˜£þ�È´9RU%’=1I9¡Í&âeÉ²”Ân—9ðÑSòÉ¸µûtW)º	ÉÚ:LÇf]Æ»ÇBüÛºÈ¤eÔæoèËÏ‚8Êú?�™{õïÜ×bÍfŒ!£ÖßoBÈÆˆÞhÿ–¾ÉS„Jê­rSEüfÙÌÿÙfWV	°Ä’ÑQO6u¡¯Å80xì¯HiÌƒS*Ây-tRw¦Y¬éËg5{£ZPb½    Y 0ÉUãß ò¤v  ýaši±Ägû    YZ  Q      <®ZTR

BASE      &Í  xÁA  ƒ°YãxÔ þµ,9 áp¡ŒÂ™D›ÒÆ¦¬A)ê¶¶IŽp)9fŽÙd4ÈÅ ªVb	¶&¹&J&TVR’«š–U´ÀÓV	Y›ÒÍFFª
hƒ‚¦’UUP–4€ˆÂ±Í¢d0«ËrÊØª-a™BÂVËÍZ†Ö”`´lK W[ŒpµbÌAeÑ¨hTEQ@°" €`-B 
XÃ,¶* Pe�f¥-¶d«Y™l“Æ–3‹Šh†nºå€R5H”Rµ r-WEƒJ*VÑB ’ €1Èª`ÂF•–åæ�I¢Ãrk[m h@¢¬l„6I´*°I–Ð¦…–%›°B%HR“ÉF¬ÍÁhØ'  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  t     _®ZTR

BASE      IH  xÁA  ƒ°YãxÔ þµ,¹ªbA $I0 œºA1k³	sN PMê*Æ¦
ÛV4cEsÓÙdËáFZ„!ÈVÛ·Ø6¤FQ%M"É“¬j),I©F[€U­�llÕˆÕ¨µÍJªÕ´ÆˆZVµ�b­ª‹‚•”ÖÌJ‘É –`•2¢ÌjÒr´lr)	+Édš©P.ŒY…Md@Ö–QÐV“¤ IÍÊXH-fÑh(Š¶HÍQi˜’D“-M³1’Y6Ó”F››95b�å¢(Ý!K°e5´Za˜Y:�–‹2š-Z16‰d™bƒ)ddk¸IV”H‘µÒV 4«ˆ´RªHZÂ–eŽ YˆÙJYVÆ´F‰e›À¶i�ÌZµUÛ€�K¡–%`mSË­ÊÃV‘n@J«õî88  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  ]     H®ZTR

BASE      2ó  xÁA  ƒ°YãxÔ þµ,9JH
TNÝ ˜µÙ„9' ¨&Œé*Æ¦
ÛV4cEsÓÙdËáFZ4C�­¶n±mH�
6¢JšD’1&YÔRX’R�¶ «ZÙØª«Qk›	”T«i�µ¬jÅZU+)­™•"“A,Á*eD™Õ¤å*hÙäRV’É4S¡\³
›È€¬-£ ­&IA“š•±�ZÌ¢ÑPl�š£Ò0%‰&[šfc$³l¦)�67sjÄËE!Pº9B–`ËjhµÂ0³t4-'e4[&´blÉ2ÅSÈÈÖp“¬(‘"k!¤­@hVi¤T	�´„-Ë É f+eYÓ¥X¶jj,™´j«Ú,hê¡¼  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  s<AlignableSequences trimStringency="Medium"><Sequence name="21_T7_TSS20210713-027-04790_B01" ID="0" use="0" sortOrder="0" trimmedRange="309..664"/><Sequence name="3_ADH1-R_TSS20210720-027-07750_A01" ID="1" use="0" sortOrder="1" trimmedRange="17..1094"/><Sequence name="4_ADH1-R_TSS20210720-027-07750_B01" ID="2" sortOrder="2" trimmedRange="0..1005"/></AlignableSequences>  Ò‹     ÿ BC N srôe”```pðpáó³2Ô3ãö·²*Í+Î/*IMábÊqqQjZjQj^r*ƒ« ÆÍÀ~6   ‹     ÿ BC fí—AŽ\5†_B€4åÔ¢–”å…Å* 6±(Ëf‡@â\¡¬ZÔ’#ÀrØ³ÈAX .þ7Ó‘&s "P—Ú²ÛÏ¯]®îþ¿÷ÿùîq¿>=ŽÇ¯¾)èŽ?žoÄóãûgÇñ£ßß?ŽïÐ^~pŸcŽŒÔ[YE-ËØ"³Êä¡Ëdkm3¦nó6¥JãŽ×`1inÞ�¨ÖAk—Ô¡{�¢{SîÜ’R¤eŽ¾3eQ—²{§•*=††—Þm»›d:EÁÀeTé™V�²o1o<»§÷œÓCmf,å½U”WìÙc{M\ ôFdaÄs˜H´åŠ‚;Ih`¿î�ìû¦89§Â9Ü•2‰£ìä…´
Ø‰—á =køÜØ¯g×é>Äæ¸Eµ"�YçFµzíbEPÀÌ…r¬Õrc7l®éŽ*È*8›:66;Mƒ¦ p„zµa:D«õ=c•ÈIµ {­œÝ¼¢ÒJå¼©é›btœ¾o>¿Ô;’n	\È|ÍF¯®q�kü/â£÷î4ý“'wzÿñqs|ýÎ›zÿéÁ�Žã[Œ
Ú—þ9ZEûéòþç{×ïÏ¿¸·þì{°þå¥¿ytYÿø®?¾¸ëÿB#ËÝÌ‰7­®XÏªœA¦ÆÙ¢ªT‰fîâ³ÖŒÊø(7²>I‡C=;»n3.=
Ô/Òì:>$’0ôWŠ êR5·œPÇ0ƒz”ºHpashAk·èžÐáÅ^ˆ—"= #|�Å^<îâ>‡�Vçš|ÒÈöf¶Y Âb1 ºÄQY¹u%Çšø`ç^(¼3±Ê ã,´h’[%ÔÔ\HÞW®b“yøZk²!à@T+2ˆ™8=É–ÖeG_“Êv.¾ÀRìzö(AÑ)epU°²ø7Ô¶žk°>kh=ð}øY®Þ±¹‡x¸»h²k/ÍG¥‰9ÛnÛÀ 1ëê(c©=æ ÝË\=x. ¼µŽ%Ê<œ©{‚è»yÛÿ¤k\ãÿùøêéô~¼ ñC ñïè³ã—×°»@ëxÝ	X]àwö'4çÙà2šßª(°�­[ç©’õ�‡„Ê[Bm8$²Š%P;¨(Ø³°A]Ys9†	¤œ�åÈËh»°°  º&—9¥TÓNÀ§/�þƒQÍ˜ÙÎø–´:¡î.ÅºváÙ¸¬�lƒ	D…Øcµ†úÎž íA”rÂÀEíS‹-80x� š´© €4ûŒä;°k•Ólv³ Ž,–M·œWO'ƒC£|zö •ÁØ AÝÁZ€¾Ðš‰®«€1`¦Â	�6joºày`³àÖ8p‹F�ó£¼-×v;KtëkÂÉ:×áJ_W#UW–¹�:�Sx®˜ä§ÃfsÂeŽ1rpÅée7X¤Qà“ÉÛþ9_ã×ø7ãôP‡ðB  ‹     ÿ BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  s<?xml version="1.0"?><Features nextValidID="15"><Feature recentID="0" name="MP58" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1287-1754" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MAFKEIAMFSSLVVVIISYNVLESNALMMQPLIDQDFCAVKASLYELGEAEMNLMDDSQTLNDMQREYFAGKVDYSAVERARNELNKSKNKWFQKVIQYLKATNEFEPTINYQTSDPQKVYHQMDDLDNYKDALDDMHENILKSMSPTVAQPVVA*"/></Q></Feature><Feature recentID="1" name="2Î¼ ori" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4593-5935" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast 2Î¼ plasmid origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="Kan" directionality="2" translationMW="28979.67" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3667-4461" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKASMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="3" name="ADH1 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="30-734" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for&amp;nbsp;alcohol dehydrogenase 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="TRP1" directionality="1" translationMW="24145.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="6476-7150" color="#ff7f50" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae TRP1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast auxotrophic marker&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;phosphoribosylanthranilate isomerase, required for tryptophan biosynthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSVINFTGSSGPLVKVCGLQSTEAAECALDSDADLLGIICVPNRKRTIDPVIARKISSLVKAYKNSSGTPKYLVGVFRNQPKEDVLALVNDYGIDIVQLHGDESWQEYQEFLGLPVIKRLVFPKDCNILLSAASQKPHSFIPLFDSEAGGTGELLDWNSISDWVGRQESPESLHFMLAGGLTPENVGDALRLNGVIGVDVSGGVETNGVKDSNKIANFVKNAKK*"/></Q></Feature><Feature recentID="5" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2471-3059" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="f1 ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7253-7708" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="GAL4 DNA binding domain" directionality="1" translationMW="16868.03" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1754" maxFusedRunOn="1754"><Segment range="762-1202" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Saccharomyces cerevisiae GAL4&lt;/i&gt;&amp;nbsp;(truncated)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;DNA binding domain of the GAL4 transcriptional activator&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVS"/></Q></Feature><Feature recentID="8" name="TRP1 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6194-6475" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae TRP1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ADH1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1858-2045" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for the &lt;i&gt;S. cerevisiae&lt;/i&gt; alcohol dehydrogenase 1 (&lt;i&gt;ADH1&lt;/i&gt;) gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4462-4566" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="T7 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1784-1831" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HSV TK poly(A) signal" type="polyA_signal" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3388-3435" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="Myc" directionality="1" translationMW="1203.34" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1754" maxFusedRunOn="1754" detectionMode="exactProteinMatch"><Segment range="1251-1280" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Myc (human c-Myc proto-oncogene) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="EQKLISEEDL"/></Q></Feature><Feature recentID="14" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1213-1231" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  –<Notes>
<UUID>dc63a02b-5068-402b-9b2e-bc101ddb84fc</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pGBKT7-MP58</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="2:53:36">2018.6.20</Created>
<LastModified UTC="20:8:15">2025.9.3</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
